Its recommend that you exfoliate your skin 1 to 2 times a week. Skin Rx Clinic Microdermabrasion Peel gently buffs away dulling surface flakes, unclogs pores and renews, refines and retexturizes skin as it exfoliates. It does not matter whether you exfoliate morning or night, but be sure to cleanse and tone your skin first as exfoliators are not cleansers.